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Growth & Healing
TB-500 10mg
✓ 99.5% Purity (HPLC)
Molecular Weight
4963.5 g/mol
CAS Number
77591-33-4
Form
Lyophilized powder
Use
Research only
$75.00
We accept
- Ships within 1–2 business days, discreetly packaged
- Lyophilized for research flexibility
- Third-party HPLC & endotoxin tested per batch
About
What is TB-500 10mg?
TB-500 is a synthetic version of a fragment of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide found in nearly all mammalian cells. TB-500 contains the active region of Tβ4 responsible for its actin-binding and cell-migration properties.
Mechanism of Action
Thymosin Beta-4 and its active fragments bind G-actin monomers, regulating actin polymerization dynamics critical to cell migration, angiogenesis, and wound closure. Published research has characterized its effects on endothelial cell movement, cardiac progenitor activity, and integrin-linked kinase signaling.
Discovery & Context
Thymosin Beta-4 was first isolated from bovine thymus by Goldstein and colleagues in 1981. Its wound-repair and cardiovascular research applications have been studied extensively in in-vitro and animal-model settings since the 2000s.
Research use only. Language such as "may," "appears to," and "has been shown in published studies" is used throughout to reflect the pre-clinical nature of this literature. Not intended for human consumption, diagnosis, or treatment.
Background
Research Context
Published research literature covers the following areas:
- Actin sequestration dynamics
- Wound repair models
- Cardiac and skeletal muscle research
- Angiogenic signaling
- Hair follicle and dermal studies
LAR supplies this compound as a reference standard to qualified laboratories. No dosing schedules, administration methods, or human-use guidance is provided or implied.
Literature
Selected References
- Malinda KM. et al. (1999). Thymosin beta 4 accelerates wound healing. Journal of Investigative Dermatology, 113(3), 364–368. PubMed 10469335 ↗
- Bock-Marquette I. et al. (2004). Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature, 432(7016), 466–472. PubMed 15565145 ↗
- Goldstein AL. et al. (2005). Thymosin β4: actin-sequestering protein moonlights to repair injured tissues. Trends in Molecular Medicine, 11(9), 421–429. PubMed 16099219 ↗
Handling
Storage & Stability
Sealed vial: Stable at refrigerated temperatures (2–8 °C) for up to 24 months. Stable at room temperature (up to 25 °C) for 30 days during shipping.
After opening: Refrigerate at 2–8 °C and use within 30 days. Protect from light. Do not freeze after opening.
Visual check: Solution should remain clear. Discard if discoloration or precipitate appears.
Lab Work
Certificate of Analysis
Every batch is independently tested for purity, mass, and endotoxin load. Click any report to view the full analysis.
Often Studied With
Pairs Well With
Questions
Frequently Asked
Is this FDA approved?
No. Research peptides supplied by LAR are reference materials for laboratory investigation. They are not approved by the FDA or any national regulatory body for human use.
Does this vial require reconstitution?
Yes. Vials ship as lyophilized powder, giving your lab control over solvent selection and final concentration. Reconstitution should follow your laboratory's standard practice.
How is purity verified?
Each manufacturing batch is tested by an independent third-party laboratory using HPLC-UV analysis. The full report, including chromatogram and mass spectrometry, is available above.
How long does shipping take?
Orders ship within 1–2 business days via discreet packaging.
