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Skin & Recovery
Melanotan 2 10mg
✓ 99.5% Purity (HPLC)
Molecular Weight
1024.2 g/mol
CAS Number
121062-09-6
Form
Lyophilized powder
Use
Research only
$75.00
We accept
- Ships within 1–2 business days, discreetly packaged
- Lyophilized for research flexibility
- Third-party HPLC & endotoxin tested per batch
About
What is Melanotan 2 10mg?
Melanotan 2 (MT-2) is a synthetic cyclic lactam peptide analogue of α-melanocyte-stimulating hormone (α-MSH), first synthesized at the University of Arizona in the 1980s. Structurally it is a truncated, stabilized seven-residue cyclic peptide (Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH₂) with broad melanocortin receptor activity.
Mechanism of Action
MT-2 is a non-selective agonist of the melanocortin receptors (MC1R–MC5R), with strongest binding affinity at MC1R (melanogenesis) and MC4R (central effects including appetite modulation and sexual arousal signaling). It does not discriminate between receptor subtypes as selectively as newer analogues like PT-141 or afamelanotide.
Discovery & Context
Developed as part of research into sun-protective peptides led by Hadley and Hruby. Its structural optimization eventually led to afamelanotide (Scenesse), an FDA-approved medication for erythropoietic protoporphyria. MT-2 itself remains a pre-clinical research compound.
Research use only. Language such as "may," "appears to," and "has been shown in published studies" is used throughout to reflect the pre-clinical nature of this literature. Not intended for human consumption, diagnosis, or treatment.
Background
Research Context
Published research literature covers the following areas:
- Melanocortin receptor binding profiles
- Tyrosinase and melanogenesis pathways
- MC4R-mediated central signaling
- Comparative studies vs. afamelanotide
- Cyclic peptide stability research
LAR supplies this compound as a reference standard to qualified laboratories. No dosing schedules, administration methods, or human-use guidance is provided or implied.
Literature
Selected References
- Dorr RT. et al. (1996). Evaluation of Melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sciences, 58(20), 1777–1784. PubMed 8637402 ↗
- Hadley ME. & Dorr RT. (2006). Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides, 27(4), 921–930. PubMed 16412534 ↗
- Al-Obeidi F. et al. (1989). Design of a new class of superpotent cyclic α-melanotropins based on quenched dynamic simulations. Journal of the American Chemical Society, 111(9), 3413–3416.
Handling
Storage & Stability
Sealed vial: Stable at refrigerated temperatures (2–8 °C) for up to 24 months. Stable at room temperature (up to 25 °C) for 30 days during shipping.
After opening: Refrigerate at 2–8 °C and use within 30 days. Protect from light. Do not freeze after opening.
Visual check: Solution should remain clear. Discard if discoloration or precipitate appears.
Lab Work
Certificate of Analysis
Every batch is independently tested for purity, mass, and endotoxin load. Click any report to view the full analysis.
Often Studied With
Pairs Well With
Questions
Frequently Asked
Is this FDA approved?
No. Research peptides supplied by LAR are reference materials for laboratory investigation. They are not approved by the FDA or any national regulatory body for human use.
Does this vial require reconstitution?
Yes. Vials ship as lyophilized powder, giving your lab control over solvent selection and final concentration. Reconstitution should follow your laboratory's standard practice.
How is purity verified?
Each manufacturing batch is tested by an independent third-party laboratory using HPLC-UV analysis. The full report, including chromatogram and mass spectrometry, is available above.
How long does shipping take?
Orders ship within 1–2 business days via discreet packaging.
