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Skin & Recovery
KPV 10mg
✓ 99.85% Purity (HPLC)
Molecular Weight
342.43 g/mol
CAS Number
67727-97-3
Form
Lyophilized powder
Use
Research only
$75.00
We accept
- Ships within 1–2 business days, discreetly packaged
- Lyophilized for research flexibility
- Third-party HPLC & endotoxin tested per batch
About
What is KPV 10mg?
KPV is a tripeptide (H-Lys-Pro-Val-OH) representing the C-terminal 11-13 fragment of α-melanocyte-stimulating hormone (α-MSH). It retains much of the anti-inflammatory pathway activity of the parent molecule without the pigmentary effects associated with N-terminal melanocortin receptor binding.
Mechanism of Action
Published studies describe KPV inhibiting NF-κB nuclear translocation, reducing pro-inflammatory cytokine output (TNF-α, IL-1β, IL-6) in activated immune cells, and influencing intestinal epithelial barrier integrity through tight junction protein expression.
Discovery & Context
Identified as the smallest active fragment of α-MSH during structure-activity research in the 1990s and early 2000s. Continues to appear in inflammation and mucosal biology literature.
Research use only. Language such as "may," "appears to," and "has been shown in published studies" is used throughout to reflect the pre-clinical nature of this literature. Not intended for human consumption, diagnosis, or treatment.
Background
Research Context
Published research literature covers the following areas:
- NF-κB pathway inhibition
- Intestinal barrier and IBD models
- Dermatological inflammation research
- Pro-inflammatory cytokine modulation
- Melanocortin fragment pharmacology
LAR supplies this compound as a reference standard to qualified laboratories. No dosing schedules, administration methods, or human-use guidance is provided or implied.
Literature
Selected References
- Dalmasso G. et al. (2008). PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology, 134(1), 166–178. PubMed 18061177 ↗
- Kannengiesser K. et al. (2008). Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflammatory Bowel Diseases, 14(3), 324–331. PubMed 18092346 ↗
Handling
Storage & Stability
Sealed vial: Stable at refrigerated temperatures (2–8 °C) for up to 24 months. Stable at room temperature (up to 25 °C) for 30 days during shipping.
After opening: Refrigerate at 2–8 °C and use within 30 days. Protect from light. Do not freeze after opening.
Visual check: Solution should remain clear. Discard if discoloration or precipitate appears.
Lab Work
Certificate of Analysis
Every batch is independently tested for purity, mass, and endotoxin load. Click any report to view the full analysis.
Often Studied With
Pairs Well With
Questions
Frequently Asked
Is this FDA approved?
No. Research peptides supplied by LAR are reference materials for laboratory investigation. They are not approved by the FDA or any national regulatory body for human use.
Does this vial require reconstitution?
Yes. Vials ship as lyophilized powder, giving your lab control over solvent selection and final concentration. Reconstitution should follow your laboratory's standard practice.
How is purity verified?
Each manufacturing batch is tested by an independent third-party laboratory using HPLC-UV analysis. The full report, including chromatogram and mass spectrometry, is available above.
How long does shipping take?
Orders ship within 1–2 business days via discreet packaging.
