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In Stock
Metabolic
Glutathione 2000mg
✓ 99.75% Purity (HPLC)
Molecular Weight
307.32 g/mol
CAS Number
70-18-8
Form
Lyophilized powder
Use
Research only
$200.00
We accept
- Ships within 1–2 business days, discreetly packaged
- Lyophilized for research flexibility
- Third-party HPLC & endotoxin tested per batch
About
What is Glutathione 2000mg?
Glutathione is the dominant intracellular antioxidant in mammalian cells, present at millimolar concentrations across most tissues. Its tripeptide structure combines glutamate, cysteine, and glycine through an atypical gamma-peptide bond at the glutamate residue. That unusual linkage keeps the molecule resistant to most cellular proteases, which is why intracellular pools remain stable under normal conditions.
Mechanism of Action
The cysteine thiol group donates electrons to reactive oxygen species and oxidized protein residues, reducing them to harmless forms. The oxidized glutathione disulfide (GSSG) that results gets recycled back to active GSH by glutathione reductase using NADPH. A separate pathway uses glutathione as a conjugating substrate through glutathione S-transferases, tagging xenobiotics and reactive metabolic byproducts for excretion through bile or urine.
Discovery & Context
Joseph de Rey-Pailhade described the molecule in 1888, calling it philothion. Frederick Gowland Hopkins worked out its tripeptide structure in the 1920s. Its role in phase II detoxification was established through work at the NIH in the 1950s and has remained a staple of cellular biochemistry research since.
Research use only. Language such as "may," "appears to," and "has been shown in published studies" is used throughout to reflect the pre-clinical nature of this literature. Not intended for human consumption, diagnosis, or treatment.
Background
Research Context
Published research literature covers the following areas:
- Redox homeostasis
- Phase II detoxification pathways
- Oxidative stress models
- Xenobiotic metabolism
- Cellular immunology research
LAR supplies this compound as a reference standard to qualified laboratories. No dosing schedules, administration methods, or human-use guidance is provided or implied.
Literature
Selected References
- Forman HJ., Zhang H. & Rinna A. (2009). Glutathione: overview of its protective roles, measurement, and biosynthesis. Molecular Aspects of Medicine, 30(1-2), 1–12. PubMed 18796312 ↗
- Meister A. (1988). Glutathione metabolism and its selective modification. Journal of Biological Chemistry, 263(33), 17205–17208. PubMed 3053703 ↗
- Lu SC. (2013). Glutathione synthesis. Biochimica et Biophysica Acta, 1830(5), 3143–3153. PubMed 22995213 ↗
Handling
Storage & Stability
Sealed vial: Stable at refrigerated temperatures (2–8 °C) for up to 24 months. Stable at room temperature (up to 25 °C) for 30 days during shipping.
After opening: Refrigerate at 2–8 °C and use within 30 days. Protect from light. Do not freeze after opening.
Visual check: Solution should remain clear. Discard if discoloration or precipitate appears.
Lab Work
Certificate of Analysis
Every batch is independently tested for purity, mass, and endotoxin load. Click any report to view the full analysis.
Often Studied With
Pairs Well With
Questions
Frequently Asked
Is this FDA approved?
No. Research peptides supplied by LAR are reference materials for laboratory investigation. They are not approved by the FDA or any national regulatory body for human use.
Does this vial require reconstitution?
Yes. Vials ship as lyophilized powder, giving your lab control over solvent selection and final concentration. Reconstitution should follow your laboratory's standard practice.
How is purity verified?
Each manufacturing batch is tested by an independent third-party laboratory using HPLC-UV analysis. The full report, including chromatogram and mass spectrometry, is available above.
How long does shipping take?
Orders ship within 1–2 business days via discreet packaging.
