TA1 Complex 3.2mg Thymosin Alpha 1, 50mg AMPK Activator, 25mg RG3/25mg UA 2.5mg Thymalin

Thymosin alpha 1 is a 28 amino acid peptide with sequence matching the N-terminal fragment of prothymosin alpha, a protein originally isolated from calf thymus. The compound enters immunology research primarily through its effects on plasmacytoid dendritic cells and downstream T-cell activation.

Mechanism of Action

Binding Toll-like receptor 9 on plasmacytoid dendritic cells triggers a signaling cascade that increases type I interferon output and shifts cytokine profiles toward a Th1-biased response. Separate work describes direct effects on T-cell maturation in the thymus and on natural killer cell activity. The combination of receptor effects makes Tα1 useful in research examining innate-to-adaptive immune crosstalk.

Discovery & Context

Allan Goldstein isolated the parent thymic fraction at Albert Einstein College of Medicine in 1965. His group at George Washington University characterized the 28 amino acid active fragment in 1977. The compound gained regulatory approval for hepatitis B and cancer supportive care in more than 35 countries during the 1990s and 2000s under the brand name Zadaxin, though not in the United States or the European Union.

Published research literature covers the following areas:

• T-cell maturation
• Interferon and TLR9 signaling
• Cytokine Th1/Th2 balance
• Immune reconstitution studies
• Viral hepatitis research

LAR supplies this compound as a reference standard to qualified laboratories. No dosing schedules, administration methods, or human-use guidance is provided or implied.

1. Goldstein AL. & Badamchian M. (2004). Thymosins: chemistry and biological properties in health and disease. Expert Opinion on Biological Therapy, 4(4), 559–573. PubMed 15102605 ↗
2. Camerini R. & Garaci E. (2015). Historical review of thymosin α1 in infectious diseases. Expert Opinion on Biological Therapy, 15 Suppl 1, S117–S127. PubMed 26092605 ↗
3. Romani L. et al. (2012). Thymosin α1: an endogenous regulator of inflammation, immunity, and tolerance. Annals of the New York Academy of Sciences, 1269, 26–33. PubMed 23045966 ↗

Sealed vial: Stable at refrigerated temperatures (2–8 °C) for up to 24 months. Stable at room temperature (up to 25 °C) for 30 days during shipping.

After opening: Refrigerate at 2–8 °C and use within 30 days. Protect from light. Do not freeze after opening.

Visual check: Solution should remain clear. Discard if discoloration or precipitate appears.

Every batch is independently tested for purity, mass, and endotoxin load. Click any report to view the full analysis.