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In Stock
Cognitive
Semax 20mg
✓ 99.8% Purity (HPLC)
Molecular Weight
813.92 g/mol
CAS Number
80714-61-0
Form
Lyophilized powder
Use
Research only
$95.00
We accept
- Ships within 1–2 business days, discreetly packaged
- Lyophilized for research flexibility
- Third-party HPLC & endotoxin tested per batch
About
What is Semax 20mg?
Semax is a Russian-synthesized heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the 4-10 fragment of adrenocorticotropic hormone (ACTH), with a C-terminal Pro-Gly-Pro extension added for metabolic stability. It is characterized in Eastern European pharmacology literature as a neuropeptide research compound.
Mechanism of Action
Published studies describe Semax increasing BDNF and NGF expression in the hippocampus in animal models, as well as modulating dopaminergic and serotonergic signaling. It reaches the CNS rapidly after intranasal administration in research settings.
Discovery & Context
Developed at the Institute of Molecular Genetics in Moscow in the 1980s. Listed on the Russian Federation essential medicines list, though not approved by the FDA or EMA.
Research use only. Language such as "may," "appears to," and "has been shown in published studies" is used throughout to reflect the pre-clinical nature of this literature. Not intended for human consumption, diagnosis, or treatment.
Background
Research Context
Published research literature covers the following areas:
- BDNF and NGF expression
- Nootropic pathway studies
- Ischemic neuroprotection models
- Dopaminergic signaling
- ACTH fragment structure-activity relationships
LAR supplies this compound as a reference standard to qualified laboratories. No dosing schedules, administration methods, or human-use guidance is provided or implied.
Literature
Selected References
- Ashmarin IP. et al. (2005). Nootropic analog of adrenocorticotropin 4-10 — Semax (15 years experience in its design and study). Zhurnal Vysshei Nervnoi Deyatelnosti, 47(2), 420–430. PubMed 9297480 ↗
- Dolotov OV. et al. (2006). Semax, an analog of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor in the rat basal forebrain. Journal of Neurochemistry, 97(Suppl 1), 82–86. PubMed 16635253 ↗
Handling
Storage & Stability
Sealed vial: Stable at refrigerated temperatures (2–8 °C) for up to 24 months. Stable at room temperature (up to 25 °C) for 30 days during shipping.
After opening: Refrigerate at 2–8 °C and use within 30 days. Protect from light. Do not freeze after opening.
Visual check: Solution should remain clear. Discard if discoloration or precipitate appears.
Lab Work
Certificate of Analysis
Every batch is independently tested for purity, mass, and endotoxin load. Click any report to view the full analysis.
Often Studied With
Pairs Well With
Questions
Frequently Asked
Is this FDA approved?
No. Research peptides supplied by LAR are reference materials for laboratory investigation. They are not approved by the FDA or any national regulatory body for human use.
Does this vial require reconstitution?
Yes. Vials ship as lyophilized powder, giving your lab control over solvent selection and final concentration. Reconstitution should follow your laboratory's standard practice.
How is purity verified?
Each manufacturing batch is tested by an independent third-party laboratory using HPLC-UV analysis. The full report, including chromatogram and mass spectrometry, is available above.
How long does shipping take?
Orders ship within 1–2 business days via discreet packaging.
