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Metabolic
MOTS-C 10mg “Los Feliz”
✓ 99.8% Purity (HPLC)
Molecular Weight
2174.62 g/mol
CAS Number
1627580-64-6
Form
Lyophilized powder
Use
Research only
$85.00
We accept
- Ships within 1–2 business days, discreetly packaged
- Lyophilized for research flexibility
- Third-party HPLC & endotoxin tested per batch
About
What is MOTS-C 10mg “Los Feliz”?
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S ribosomal RNA gene — making it one of the first characterized "mitochondrial-derived peptides" (MDPs). Identified in 2015, it is an active area of research in mitochondrial bioenergetics and metabolic homeostasis.
Mechanism of Action
Published studies describe MOTS-c translocating to the nucleus under metabolic stress, modulating AMPK pathway activation, and influencing insulin sensitivity and mitochondrial biogenesis in animal models.
Discovery & Context
Characterized and named by the Lee laboratory at USC in 2015. Represents a growing class of short peptides encoded by mitochondrial DNA that participate in cellular signaling.
Research use only. Language such as "may," "appears to," and "has been shown in published studies" is used throughout to reflect the pre-clinical nature of this literature. Not intended for human consumption, diagnosis, or treatment.
Background
Research Context
Published research literature covers the following areas:
- AMPK pathway activation
- Mitochondrial biogenesis
- Insulin sensitivity in metabolic models
- Aging and longevity research
- MDP family characterization
LAR supplies this compound as a reference standard to qualified laboratories. No dosing schedules, administration methods, or human-use guidance is provided or implied.
Literature
Selected References
- Lee C. et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443–454. PubMed 25738459 ↗
- Kim SJ. et al. (2018). Mitochondrially derived peptides as novel regulators of metabolism. Journal of Physiology, 596(13), 2855–2866. PubMed 29390147 ↗
Handling
Storage & Stability
Sealed vial: Stable at refrigerated temperatures (2–8 °C) for up to 24 months. Stable at room temperature (up to 25 °C) for 30 days during shipping.
After opening: Refrigerate at 2–8 °C and use within 30 days. Protect from light. Do not freeze after opening.
Visual check: Solution should remain clear. Discard if discoloration or precipitate appears.
Lab Work
Certificate of Analysis
Every batch is independently tested for purity, mass, and endotoxin load. Click any report to view the full analysis.
Often Studied With
Pairs Well With
Questions
Frequently Asked
Is this FDA approved?
No. Research peptides supplied by LAR are reference materials for laboratory investigation. They are not approved by the FDA or any national regulatory body for human use.
Does this vial require reconstitution?
Yes. Vials ship as lyophilized powder, giving your lab control over solvent selection and final concentration. Reconstitution should follow your laboratory's standard practice.
How is purity verified?
Each manufacturing batch is tested by an independent third-party laboratory using HPLC-UV analysis. The full report, including chromatogram and mass spectrometry, is available above.
How long does shipping take?
Orders ship within 1–2 business days via discreet packaging.
