NAD+ – "Malibu" 1000mg

Nicotinamide adenine dinucleotide sits at the center of cellular energy biochemistry. The coenzyme cycles between oxidized (NAD+) and reduced (NADH) forms across glycolysis, the citric acid cycle, and oxidative phosphorylation. Beyond its redox role, NAD+ is a required substrate for a separate set of enzymes that includes the sirtuin deacetylases (SIRT1 through SIRT7), PARP proteins involved in DNA repair, and cyclic ADP-ribose synthases.

Mechanism of Action

Sirtuin enzymes consume one NAD+ molecule for every deacetylation reaction, producing nicotinamide and O-acetyl-ADP-ribose as byproducts. This consumption makes cellular NAD+ concentrations a rate-limiting input for sirtuin activity. PARP enzymes draw from the same pool during DNA damage response, which creates competition between repair signaling and deacetylation work under stress conditions.

Discovery & Context

Arthur Harden and William Young identified the molecule in 1906 while studying fermentation in yeast extracts. Otto Warburg described its coenzyme role in the 1930s. Research interest expanded substantially after 2000 when Leonard Guarente's lab at MIT linked NAD+ to sirtuin-mediated lifespan effects in yeast, followed by work on mammalian models.

Published research literature covers the following areas:

• Sirtuin-mediated deacetylation
• Mitochondrial bioenergetics
• PARP DNA-repair studies
• Cellular senescence and aging
• NAD+ precursor research (NR, NMN)

LAR supplies this compound as a reference standard to qualified laboratories. No dosing schedules, administration methods, or human-use guidance is provided or implied.

1. Verdin E. (2015). NAD+ in aging, metabolism, and neurodegeneration. Science, 350(6265), 1208–1213. PubMed 26785480 ↗
2. Rajman L., Chwalek K. & Sinclair DA. (2018). Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metabolism, 27(3), 529–547. PubMed 29514064 ↗
3. Covarrubias AJ. et al. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, 22(2), 119–141. PubMed 33235391 ↗

Sealed vial: Stable at refrigerated temperatures (2–8 °C) for up to 24 months. Stable at room temperature (up to 25 °C) for 30 days during shipping.

After opening: Refrigerate at 2–8 °C and use within 30 days. Protect from light. Do not freeze after opening.

Visual check: Solution should remain clear. Discard if discoloration or precipitate appears.

Every batch is independently tested for purity, mass, and endotoxin load. Click any report to view the full analysis.